|Other Accession||NP_001005738.1, NP_001453.1|
|Other Names||N-formyl peptide receptor 2, FMLP-related receptor I, FMLP-R-I, Formyl peptide receptor-like 1, HM63, Lipoxin A4 receptor, LXA4 receptor, RFP, FPR2, FPRH1, FPRL1, LXA4R|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||FPRH1, FPRL1, LXA4R|
|Function||Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized.|
|Tissue Location||Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis|
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Yang, E.M., et al. Ann. Allergy Asthma Immunol. 105(1):96-97(2010)Kretschmer, D., et al. Cell Host Microbe 7(6):463-473(2010)Lee, H.Y., et al. Exp. Mol. Med. 42(4):302-309(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Kim, S.D., et al. J. Immunol. 183(9):5511-5517(2009)
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