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LNPEP Antibody (N-Term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9UIQ6
Other Accession NP_005566.2, NP_787116.2
Clone Names 91023019
Peptide ID 91023019
Additional Information
Gene ID 4012
Other Names Leucyl-cystinyl aminopeptidase, Cystinyl aminopeptidase, Insulin-regulated membrane aminopeptidase, Insulin-responsive aminopeptidase, IRAP, Oxytocinase, OTase, Placental leucine aminopeptidase, P-LAP, Leucyl-cystinyl aminopeptidase, pregnancy serum form, LNPEP, OTASE
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms OTASE
Function Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.
Cellular Location Cell membrane; Single-pass type II membrane protein. Note=In brain only the membrane- bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases
Tissue Location Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon
Research Areas
Citations (0)

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This gene encodes a zinc-dependent aminopeptidase thatcleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin,dynorphin A and other peptide hormones. The protein can be secretedin maternal serum, reside in intracellular vesicles with theinsulin-responsive glucose transporter GLUT4, or form a type IIintegral membrane glycoprotein. The protein catalyzes the finalstep in the conversion of angiotensinogen to angiotensin IV (AT4)and is also a receptor for AT4. Alternative splicing results inmultiple transcript variants encoding different isoforms. [providedby RefSeq].


Georgiadou, D., et al. J. Immunol. 185(3):1584-1592(2010)Williams, P.J., et al. Placenta 31(5):448-455(2010)Landau, R., et al. Neuro Endocrinol. Lett. 31(1):63-66(2010)Johnson, M.P., et al. Hum. Genet. 126(5):655-666(2009)Saveanu, L., et al. Science 325(5937):213-217(2009)

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$ 80.00
Cat# BP10272a
Availability: In Stock
Bulk Size
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