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DENND1B Antibody (N-term)

Synthetic peptide

Product Information
Primary Accession Q6P3S1
Other Accession NP_001182145.1, NP_659414.2, NP_001182144.1
Clone Names 91230037
Peptide ID 91230037
Additional Information
Gene ID 163486
Other Names DENN domain-containing protein 1B, Connecdenn 2, Protein FAM31B, DENND1B, C1orf218, FAM31B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DENND1B (HGNC:28404)
Function Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin- mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down- modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822).
Cellular Location Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin- coated vesicle
Tissue Location Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T- cells as compared with naive T-cells
Research Areas
Citations (0)

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Marat, A.L., et al. J. Biol. Chem. 285(14):10627-10637(2010)Sleiman, P.M., et al. N. Engl. J. Med. 362(1):36-44(2010)Venter, J.C., et al. Science 291(5507):1304-1351(2001)


Clathrin (see MIM 118955)-mediated endocytosis is a majormechanism for internalization of proteins and lipids. Members ofthe connecdenn family, such as DENND1B, function as guaninenucleotide exchange factors (GEFs) for the early endosomal smallGTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptorprotein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35activation with the clathrin machinery (Marat and McPherson, 2010[PubMed 20154091]).

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$ 99.00
Cat# BP10381a
Availability: In Stock
Bulk Size
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