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SCN1B Antibody (N-Term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q07699
Other Accession NP_950238.1, NP_001028.1
Clone Names 91023133
Peptide ID 91023133
Additional Information
Gene ID 6324
Other Names Sodium channel subunit beta-1, SCN1B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCN1B
Function Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
Cellular Location Isoform 1: Cell membrane; Single- pass type I membrane protein. Perikaryon {ECO:0000250|UniProtKB:P97952}. Cell projection {ECO:0000250|UniProtKB:P97952}. Cell projection, axon {ECO:0000250|UniProtKB:Q00954}. Note=Detected at nodes of Ranvier on the sciatic nerve. {ECO:0000250|UniProtKB:Q00954}
Tissue Location The overall expression of isoform 1 and isoform 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum. Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level)
Research Areas
Citations (0)

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Voltage-gated sodium channels are heteromeric proteinsthat function in the generation and propagation of actionpotentials in muscle and neuronal cells. They are composed of onealpha and two beta subunits, where the alpha subunit provideschannel activity and the beta-1 subunit modulates the kinetics ofchannel inactivation. SCN1B encodes a sodium channel beta-1subunit. Mutations in this gene result in generalized epilepsy withfebrile seizures plus, Brugada syndrome 5, and defects in cardiacconduction. Multiple transcript variants encoding differentisoforms have been found for this gene.


Grover, S., et al. Pharmacogenomics 11(7):927-941(2010)Tan, B.H., et al. Heart Rhythm 7(6):771-778(2010)Casini, S., et al. Cardiovasc. Res. 85(4):691-700(2010)Ogawa, R., et al. Int J Clin Pharmacol Ther 48(2):109-119(2010)Watanabe, H., et al. Circ Arrhythm Electrophysiol 2(3):268-275(2009)

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$ 99.00
Cat# BP10645a
Availability: In Stock
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