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COX10 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q12887
Clone Names 90921008
Peptide ID 90921008
Additional Information
Gene ID 1352
Other Names Protoheme IX farnesyltransferase, mitochondrial, 251-, Heme O synthase, COX10
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name COX10
Function Converts protoheme IX and farnesyl diphosphate to heme O.
Cellular Location Mitochondrion membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Cytochrome c oxidase (COX), the terminal component of themitochondrial respiratory chain, catalyzes the electron transferfrom reduced cytochrome c to oxygen. This component is aheteromeric complex consisting of 3 catalytic subunits encoded bymitochondrial genes and multiple structural subunits encoded bynuclear genes. The mitochondrially-encoded subunits function inelectron transfer, and the nuclear-encoded subunits may function inthe regulation and assembly of the complex. This nuclear geneencodes heme A:farnesyltransferase, which is not a structuralsubunit but required for the expression of functional COX andfunctions in the maturation of the heme A prosthetic group of COX.This protein is predicted to contain 7-9 transmembrane domainslocalized in the mitochondrial inner membrane. A gene mutation,which results in the substitution of a lysine for an asparagine(N204K), is identified to be responsible for cytochrome c oxidasedeficiency. In addition, this gene is disrupted in patients withCMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP(hereditary neuropathy with liability to pressure palsies)deletion.


Chen, Z., et al. Oncogene 29(30):4362-4368(2010)Vitali, M., et al. J Neural Transm 116(12):1635-1641(2009)Dassa, E.P., et al. EMBO Mol Med 1(1):30-36(2009)Veluthakal, R., et al. Diabetes 56(1):204-210(2007)Coenen, M.J., et al. Ann. Neurol. 56(4):560-564(2004)

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$ 80.00
Cat# BP10714b
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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