|Other Names||Ornithine decarboxylase antizyme 2, AZ2, ODC-Az 2, OAZ2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity).|
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Ornithine decarboxylase catalyzes the conversion ofornithine to putrescine in the first and apparently rate-limitingstep in polyamine biosynthesis. The ornithine decarboxylaseantizymes play a role in the regulation of polyamine synthesis bybinding to and inhibiting ornithine decarboxylase. Antizymeexpression is auto-regulated by polyamine-enhanced translationalframeshifting. The antizyme encoded by this gene inhibits ornithinedecarboxylase but does not accelerate its degradation. [provided byRefSeq].
Geerts, D., et al. Int. J. Cancer 126(9):2012-2024(2010)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Mangold, U., et al. Biochem. J. 385 (PT 1), 21-28 (2005) :Chen, H., et al. J. Biol. Chem. 277(48):45957-45961(2002)Coffino, P. Proc. Natl. Acad. Sci. U.S.A. 97(9):4421-4423(2000)
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