|Other Names||Kelch domain-containing protein 1, KLHDC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Widely expressed, with high levels in skeletal muscle, pancreas and liver. Undetectable in peripheral blood leukocytes. EMBL; AF111806; AAL39008.1; -; mRNA EMBL; AK098735; BAC05398.1; -; mRNA EMBL; AK127202; BAG54451.1; -; mRNA EMBL; CH471078; EAW65753.1; -; Genomic_DNA EMBL; BC101595; AAI01596.1; -; mRNA EMBL; BC101597; AAI01598.1; -; mRNA CCDS; CCDS9692.1; - RefSeq; NP_751943.1; NM_172193.2 UniGene; Hs.509258; - ProteinModelPortal; Q8N7A1; - IntAct; Q8N7A1; 2 STRING; 9606.ENSP00000352282; - iPTMnet; Q8N7A1; - PhosphoSitePlus; Q8N7A1; - BioMuta; KLHDC1; - DMDM; 90110030; - PaxDb; Q8N7A1; - PeptideAtlas; Q8N7A1; - PRIDE; Q8N7A1; - ProteomicsDB; 72277; - Ensembl; ENST00000359332; ENSP00000352282; ENSG00000197776 GeneID; 122773; - KEGG; hsa:122773; - UCSC; uc001www.3; human CTD; 122773; - DisGeNET; 122773; - EuPathDB; HostDB:ENSG00000197776.7; - GeneCards; KLHDC1; - HGNC; HGNC:19836; KLHDC1 HPA; HPA020461; - MIM; 611281; gene neXtProt; NX_Q8N7A1; - OpenTargets; ENSG00000197776; - PharmGKB; PA134938689; - eggNOG; KOG0379; Eukaryota eggNOG; ENOG410Y5WM; LUCA GeneTree; ENSGT00760000119086; - HOGENOM; HOG000006587; - HOVERGEN; HBG067471; - InParanoid; Q8N7A1; - OMA; KITFWAA; - OrthoDB; EOG091G06BF; - PhylomeDB; Q8N7A1; - TreeFam; TF314081; - ChiTaRS; KLHDC1; human GenomeRNAi; 122773; - PRO; PR:Q8N7A1; - Proteomes; UP000005640; Chromosome 14 Bgee; ENSG00000197776; - CleanEx; HS_KLHDC1; - ExpressionAtlas; Q8N7A1; baseline and differential Genevisible; Q8N7A1; HS GO; GO:0005829; C:cytosol; IDA:HPA Gene3D; 220.127.116.11; -; 2 InterPro; IPR015915; Kelch-typ_b-propeller SUPFAM; SSF117281; SSF117281; 2 2: Evidence at transcript level; Complete proteome; Cytoplasm; Kelch repeat; Reference proteome; Repeat CHAIN 1 406 Kelch domain-containing protein 1 /FTId=PRO_0000119126 REPEAT 24 76 Kelch 1 REPEAT 80 134 Kelch 2 REPEAT 135 181 Kelch 3 REPEAT 208 258 Kelch 4 REPEAT 260 307 Kelch 5 REPEAT 311 361 Kelch 6 CONFLICT 32 32 V -> A (in Ref. 1; BAC05398) SEQUENCE 406 AA; 46720 MW; 73F74B22417D12E8 CRC64; MADSQLFCVA EERSGHCAVV DGNFLYVWGG YVSIEDNEVY LPNDEIWTYD IDSGLWRMHL MEGELPASMS GSCGACINGK LYIFGGYDDK GYSNRLYFVN LRTRDETYIW EKITDFEGQP PTPRDKLSCW VYKDRLIYFG GYGCRRHSEL QDCFDVHDAS WEEQIFWGWH NDVHIFDTKT QTWFQPEIKG GVPPQPRAAH TCAVLGNKGY IFGGRVLQTR MNDLHYLNLD TWTWSGRITI NGESPKHRSW HTLTPIADDK LFLCGGLSAD NIPLSDGWIH NVTTNCWKQL THLPKTRPRL WHTACLGKEN EIMVFGGSKD DLLALDTGHC NDLLIFQTQP YSLLRSCLDC IGKNSIMLES QISLLPPKLL QQVLKKITFW AAANHREEQR VQKEETENKY QWISSN|
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Provided below are standard protocols that you may find useful for product applications.
KLHDC1 contains 6 Kelch repeats and is widely expressed, with high levels in skeletal muscle, pancreas and liver. KLHDC1 and KLHDC2 have differential localization and activity in cultured mammalian cells. The exact function of KLHDC1 remains unknown.
Feng, T., et al. Hum. Genet. 128(3):269-280(2010)Chin, K.T., et al. Mol. Cell. Biochem. 296 (1-2), 109-119 (2007) :
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