|Other Names||CCAAT/enhancer-binding protein delta, C/EBP delta, Nuclear factor NF-IL6-beta, NF-IL6-beta, CEBPD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this intronless gene is a bZIPtranscription factor which can bind as a homodimer to certain DNAregulatory regions. It can also form heterodimers with the relatedprotein CEBP-alpha. The encoded protein is important in theregulation of genes involved in immune and inflammatory responses,and may be involved in the regulation of genes associated withactivation and/or differentiation of macrophages. The cytogeneticlocation of this locus has been reported as both 8p11 and 8q11.
Zannetti, C., et al. J. Biol. Chem. 285(45):34773-34780(2010)Wang, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(37):16131-16136(2010)Hour, T.C., et al. Biochem. Pharmacol. 80(3):325-334(2010)Bennett, C.E., et al. Diab Vasc Dis Res 7(3):195-203(2010)Payne, V.A., et al. Biochem. J. 425(1):215-223(2010)
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