|Other Names||B-cell lymphoma/leukemia 11B, BCL-11B, B-cell CLL/lymphoma 11B, COUP-TF-interacting protein 2, Radiation-induced tumor suppressor gene 1 protein, hRit1, BCL11B, CTIP2, RIT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T- lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC- rich response element (By similarity). May also function in the P53-signaling pathway (By similarity).|
|Tissue Location||Highly expressed in brain and in malignant T- cell lines derived from patients with adult T-cell leukemia/lymphoma|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a C2H2-type zinc finger protein and isclosely related to BCL11A, a gene whose translocation may beassociated with B-cell malignancies. The specific function of thisgene has not yet been determined. Two alternatively splicedtranscript variants, which encode distinct isoforms, have beenreported.
Ganguli-Indra, G., et al. Exp. Dermatol. 18(11):994-996(2009)Cherrier, T., et al. Oncogene 28(38):3380-3389(2009)Ganguli-Indra, G., et al. PLoS ONE 4 (4), E5367 (2009) :Cismasiu, V.B., et al. Virology 380(2):173-181(2008)Desplats, P.A., et al. Neurobiol. Dis. 31(3):298-308(2008)
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