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ANAPC5 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9UJX4
Clone Names 90819114
Peptide ID 90819114
Additional Information
Gene ID 51433
Other Names Anaphase-promoting complex subunit 5, APC5, Cyclosome subunit 5, ANAPC5, APC5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms APC5
Function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Research Areas
Citations (0)

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This gene encodes a tetratricopeptide repeat-containingcomponent of the anaphase promoting complex/cyclosome (APC/C), alarge E3 ubiquitin ligase that controls cell cycle progression bytargeting a number of cell cycle regulators such as B-type cyclinsfor 26S proteasome-mediated degradation through ubiquitination. Theencoded protein is required for the proper ubiquitination functionof APC/C and for the interaction of APC/C with transcriptioncoactivators. It also interacts with polyA binding protein andrepresses internal ribosome entry site-mediated translation.Multiple transcript variants encoding different isoforms have beenfound for this gene. These differences cause translation initiationat a downstream AUG and result in a shorter protein (isoform b),compared to isoform a.


Wasch, R., et al. Oncogene 29(1):1-10(2010)Jin, L., et al. Cell 133(4):653-665(2008)Liu, J., et al. Cancer Biol. Ther. 5(7):760-762(2006)Dube, P., et al. Mol. Cell 20(6):867-879(2005)Turnell, A.S., et al. Nature 438(7068):690-695(2005)

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$ 80.00
Cat# BP10974c
Availability: In Stock
Bulk Size
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