|Other Names||GDNF family receptor alpha-like, GFRAL, C6orf144|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.|
|Cellular Location||Cell membrane; Single-pass membrane protein; Extracellular side|
|Tissue Location||Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level) (PubMed:28846097, PubMed:28846098). Detected at low levels in testis and adipose tissue (PubMed:28846097)|
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Provided below are standard protocols that you may find useful for product applications.
Fellay, J., et al. PLoS Genet. 5 (12), E1000791 (2009) :Li, Z., et al. J. Neurochem. 95(2):361-376(2005)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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