|Other Names||Interleukin-6 receptor subunit beta, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, CDw130, Interleukin-6 signal transducer, Membrane glycoprotein 130, gp130, Oncostatin-M receptor subunit alpha, CD130, IL6ST|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).|
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The protein encoded by this gene is a signal transducershared by many cytokines, including interleukin 6 (IL6), ciliaryneurotrophic factor (CNTF), leukemia inhibitory factor (LIF), andoncostatin M (OSM). This protein functions as a part of thecytokine receptor complex. The activation of this protein isdependent upon the binding of cytokines to their receptors. vIL6, aprotein related to IL6 and encoded by the Kaposi sarcoma-associatedherpesvirus, can bypass the interleukin 6 receptor (IL6R) anddirectly activate this protein. Knockout studies in mice suggestthat this gene plays a critical role in regulating myocyteapoptosis. Alternatively spliced transcript variants encodingdistinct isoforms have been described. A related pseudogene hasbeen identified on chromosome 17.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Goette, N.P., et al. Exp. Hematol. 38(10):868-876(2010)Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Richards, P.J., et al. Arthritis Rheum. 54(5):1662-1672(2006)
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