|Other Names||Putative Polycomb group protein ASXL1, Additional sex combs-like protein 1, ASXL1, KIAA0978|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1).|
|Tissue Location||Widely expressed at low level. Expressed in heart, brain, skeletal muscle, placenta, pancreas, spleen, prostate, small intestine, colon, peripheral blood, leukocytes, bone marrow and fetal liver. Highly expressed in testes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene is similar to the Drosophila additional sexcombs gene, which encodes a chromatin-binding protein required fornormal determination of segment identity in the developing embryo.The protein is a member of the Polycomb group of proteins, whichare necessary for the maintenance of stable repression of homeoticand other loci. The protein is thought to disrupt chromatin inlocalized areas, enhancing transcription of certain genes whilerepressing the transcription of other genes. The protein encoded bythis gene functions as a ligand-dependent co-activator for retinoicacid receptor in cooperation with nuclear receptor coactivator 1.Mutations in this gene are associated with myelodysplasticsyndromes and chronic myelomonocytic leukemia. Alternative splicingresults in multiple transcript variants.
Abdel-Wahab, O., et al. Leukemia 24(9):1656-1657(2010)Szpurka, H., et al. Leuk. Res. 34(8):969-973(2010)Sugimoto, Y., et al. Br. J. Haematol. 150(1):83-87(2010)Boultwood, J., et al. Leukemia 24(6):1139-1145(2010)Rocquain, J., et al. BMC Cancer 10, 401 (2010) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.