|Other Names||E3 ubiquitin-protein ligase RNF19B, 632-, IBR domain-containing protein 3, Natural killer lytic-associated molecule, RING finger protein 19B, RNF19B, IBRDC3, NKLAM|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909). Protects against staurosporin-induced cell death (PubMed:27485036).|
|Cellular Location||Cytoplasmic granule membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells (PubMed:10438909). Present in natural killer cells (at protein level) (PubMed:10912506). Ubiquitously expressed with high expression in testis (PubMed:27485036)|
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Provided below are standard protocols that you may find useful for product applications.
IBRDC3 is a cytolysis-associated transmembrane proteinexpressed in natural killer (NK) cells and T lymphocytes followingcytokine stimulation (Kozlowski et al., 1999 [PubMed10438909]).
Fortier, J.M., et al. J. Immunol. 176(11):6454-6463(2006)Kozlowski, M., et al. J. Immunol. 163(4):1775-1785(1999)
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