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GFER Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P55789
Clone Names 71213113
Peptide ID 71213113
Additional Information
Gene ID 2671
Other Names FAD-linked sulfhydryl oxidase ALR, Augmenter of liver regeneration, hERV1, Hepatopoietin, GFER, ALR, HERV1, HPO
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ALR, HERV1, HPO
Function Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen.
Cellular Location Isoform 1: Mitochondrion intermembrane space. Mitochondrion
Tissue Location Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle
Research Areas
Citations (0)

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The hepatotrophic factor designated augmenter of liverregeneration (ALR) is thought to be one of the factors responsiblefor the extraordinary regenerative capacity of mammalian liver. Ithas also been called hepatic regenerative stimulation substance(HSS). The gene resides on chromosome 16 in the interval containingthe locus for polycystic kidney disease (PKD1). The putative geneproduct is 42% similar to the scERV1 protein of yeast. The yeastscERV1 gene had been found to be essential for oxidativephosphorylation, the maintenance of mitochondrial genomes, and thecell division cycle. The human gene is both the structural andfunctional homolog of the yeast scERV1 gene.


Dong, L.Y., et al. Biochem. J. 431(2):277-287(2010)Li, W., et al. FEBS Lett. 584(18):3929-3935(2010)Daithankar, V.N., et al. Biochemistry 49(31):6737-6745(2010)Dayoub, R., et al. Biochem. Biophys. Res. Commun. 395(4):465-470(2010)Chang, J., et al. World J. Gastroenterol. 16(2):193-200(2010)

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$ 80.00
Cat# BP11198c
Availability: In Stock
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