- CITATIONS: 1
|Other Names||Insulin-like growth factor II, IGF-II, Somatomedin-A, Insulin-like growth factor II, Insulin-like growth factor II Ala-25 Del, Preptin, IGF2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464).|
|Tissue Location||Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas|
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This gene encodes a member of the insulin family ofpolypeptide growth factors, which are involved in development andgrowth. It is an imprinted gene, expressed only from the paternalallele, and epigenetic changes at this locus are associated withWilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, andSilver-Russell syndrome. A read-through INS-IGF2 gene exists, whose5' region overlaps the INS gene and the 3' region overlaps thisgene. Alternatively spliced transcript variants encoding differentisoforms have been found for this gene.
Adkins, R.M., et al. Pediatr. Res. 68(5):429-434(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Li, J., et al. Mol. Biol. Rep. (2010) In press :Hsieh, Y.Y., et al. Anticancer Res. 30(6):2203-2208(2010)Turan, N., et al. PLoS Genet. 6 (7), E1001033 (2010) :
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