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INPP5E Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9NRR6
Clone Names 80513214
Peptide ID 80513214
Additional Information
Gene ID 56623
Other Names 72 kDa inositol polyphosphate 5-phosphatase, Phosphatidylinositol 4, 5-bisphosphate 5-phosphatase, Phosphatidylinositol polyphosphate 5-phosphatase type IV, INPP5E
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5- bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates.
Cellular Location Cytoplasm, cytoskeleton, cilium axoneme. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9JII1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JII1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JII1}. Cell membrane {ECO:0000250|UniProtKB:Q9WVR1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVR1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVR1}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9WVR1}. Cytoplasm {ECO:0000250|UniProtKB:Q9WVR1}. Note=Peripheral membrane protein associated with Golgi stacks. {ECO:0000250|UniProtKB:Q9JII1}
Tissue Location Detected in brain, heart, pancreas, testis and spleen.
Research Areas
Citations (0)

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The protein encoded by this gene is an inositol1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphataseshydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium andacts as a second messenger mediating cell responses to variousstimulation. Studies of the mouse counterpart suggest that thisprotein may hydrolyze phosphatidylinositol 3,4, 5-trisphosphate andphosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgimembrane and thereby regulate Golgi-vesicular trafficking.


Bielas, S.L., et al. Nat. Genet. 41(9):1032-1036(2009)Jacoby, M., et al. Nat. Genet. 41(9):1027-1031(2009)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)Kong, A.M., et al. J. Biol. Chem. 275(31):24052-24064(2000)

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$ 80.00
Cat# BP11230c
Availability: In Stock
Bulk Size
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