|Other Names||Myeloid cell nuclear differentiation antigen, MNDA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell- specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.|
|Cellular Location||Nucleus. Cytoplasm. Note=Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin|
|Tissue Location||Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia.|
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The myeloid cell nuclear differentiation antigen (MNDA) isdetected only in nuclei of cells of the granulocyte-monocytelineage. A 200-amino acid region of human MNDA is strikinglysimilar to a region in the proteins encoded by a family ofinterferon-inducible mouse genes, designated Ifi-201, Ifi-202, andIfi-203, that are not regulated in a cell- or tissue-specificfashion. The 1.8-kb MNDA mRNA, which contains aninterferon-stimulated response element in the 5-prime untranslatedregion, was significantly upregulated in human monocytes exposed tointerferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS,CRP, and SPTA1. In its pattern of expression and/or regulation,MNDA resembles IFI16, suggesting that these genes participate inblood cell-specific responses to interferons.
Kimkong, I., et al. J. Rheumatol. 37(7):1544-1547(2010)Kanellis, G., et al. Leukemia 23(10):1847-1857(2009)Joshi, A.D., et al. Clin. Cancer Res. 13 (18 PT 1), 5295-5304 (2007) :Briggs, R.C., et al. Cancer Res. 66(9):4645-4651(2006)Asefa, B., et al. FEBS Lett. 580(5):1205-1214(2006)
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