|Other Names||Cytochrome P450 1A2, CYPIA2, Cytochrome P(3)450, Cytochrome P450 4, Cytochrome P450-P3, CYP1A2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.The protein encoded by this gene localizes to the endoplasmicreticulum and its expression is induced by some polycyclic aromatichydrocarbons (PAHs), some of which are found in cigarette smoke.The enzyme's endogenous substrate is unknown; however, it is ableto metabolize some PAHs to carcinogenic intermediates. Otherxenobiotic substrates for this enzyme include caffeine, aflatoxinB1, and acetaminophen. The transcript from this gene contains fourAlu sequences flanked by direct repeats in the 3' untranslatedregion.
Gentile, G., et al. J Headache Pain 11(5):431-435(2010)Uslu, A., et al. BMB Rep 43(8):530-534(2010)Wang, X., et al. J. Pharm. Pharmacol. 62(8):1077-1083(2010)Schmidt, R.J., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(7):560-569(2010)Jiang, Z., et al. Pharmacogenet. Genomics 16(5):359-367(2006)
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