|Other Accession||NP_066025.2, NP_001164161.1|
|Other Names||Signal peptide, CUB and EGF-like domain-containing protein 2, Protein CEGP1, SCUBE2, CEGP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid- modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).|
|Cellular Location||Secreted. Cell surface. Note=Secreted and tethered at the cell surface (PubMed:19480626).|
|Tissue Location||Expressed in a broad spectrum of adult tissues (PubMed:12270931).|
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Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)Tsai, M.T., et al. Biochem. J. 422(1):119-128(2009)Shen, M., et al. Environ. Mol. Mutagen. 50(4):285-290(2009)
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