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TBX6 Antibody (Center W158) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O95947
Clone Names 71017107
Peptide ID 71017107
Additional Information
Gene ID 6911
Other Names T-box transcription factor TBX6, T-box protein 6, TBX6
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TBX6
Function T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00201}
Tissue Location Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus
Research Areas
Citations (0)

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This gene is a member of the inhibitor of apoptosis (IAP)gene family, which encode negative regulatory proteins that preventapoptotic cell death. IAP family members usually contain multiplebaculovirus IAP repeat (BIR) domains, but this gene encodesproteins with only a single BIR domain. The encoded proteins alsolack a C-terminus RING finger domain. Gene expression is highduring fetal development and in most tumors yet low in adulttissues. Antisense transcripts are involved in the regulation ofthis gene's expression. At least four transcript variants encodingdistinct isoforms have been found for this gene, but thefull-length natures of only three of them have been determined.


Nabilsi, N.H., et al. J. Endocrinol. 207(2):237-243(2010)Valenzuela, M., et al. J. Infect. Dis. 202(7):1021-1030(2010)Yoon, S., et al. FEBS Lett. 584(18):4048-4052(2010)Ezponda, T., et al. Clin. Cancer Res. 16(16):4113-4125(2010)Sawai, K., et al. Oncol. Res. 18 (11-12), 541-547 (2010) :

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$ 80.00
Cat# BP11675c
Availability: In Stock
Bulk Size
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