|Other Names||TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, TGFBR2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Membrane raft|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is found primarily incerebellar Purkinje cells, where it functions as a proteinphosphatase inhibitor. The encoded protein is a substrate forcGMP-dependent protein kinase. An allele of this gene wasdiscovered that increases susceptibility to hypercholesterolemia.Two transcript variants encoding different isoforms have been foundfor this gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ono, S., et al. J. Hum. Genet. 48(9):447-450(2003)Endo, S., et al. Proc. Natl. Acad. Sci. U.S.A. 96(5):2467-2472(1999)Hall, K.U., et al. J. Biol. Chem. 274(6):3485-3495(1999)
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