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CLCN7 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P51798
Other Accession NP_001278.1, NP_001107803.1
Clone Names 101008233
Peptide ID 101008233
Additional Information
Gene ID 1186
Other Names H(+)/Cl(-) exchange transporter 7, Chloride channel 7 alpha subunit, Chloride channel protein 7, ClC-7, CLCN7
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLCN7
Function Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen.
Cellular Location Lysosome membrane; Multi-pass membrane protein
Tissue Location Brain, testis, muscle and kidney.
Research Areas
Citations (0)

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The product of this gene belongs to the CLC chloridechannel family of proteins. Chloride channels play important rolesin the plasma membrane and in intracellular organelles. This geneencodes chloride channel 7. Defects in this gene are the cause ofosteopetrosis autosomal recessive type 4 (OPTB4), also calledinfantile malignant osteopetrosis type 2 as well as the cause ofautosomal dominant osteopetrosis type 2 (OPTA2), also calledautosomal dominant Albers-Schonberg disease or marble diseaseautosoml dominant. Osteopetrosis is a rare genetic diseasecharacterized by abnormally dense bone, due to defective resorptionof immature bone. OPTA2 is the most common form of osteopetrosis,occurring in adolescence or adulthood.


Furthner, D., et al. Klin Padiatr 222(3):180-183(2010)Phadke, S.R., et al. Indian J. Med. Res. 131, 508-514 (2010) :Pangrazio, A., et al. Hum. Mutat. 31 (1), E1071-E1080 (2010) :Kajiya, H., et al. Pflugers Arch. 458(6):1049-1059(2009)Mazzolari, E., et al. Am. J. Hematol. 84(8):473-479(2009)

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$ 99.00
Cat# BP11863b
Availability: 2-3 weeks
Bulk Size
Seasonal Special on Bulk Order
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