|Other Names||Glutamate--cysteine ligase catalytic subunit, GCS heavy chain, Gamma-ECS, Gamma-glutamylcysteine synthetase, GCLC, GLCL, GLCLC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Glutamate-cysteine ligase, also known asgamma-glutamylcysteine synthetase is the first rate-limiting enzymeof glutathione synthesis. The enzyme consists of two subunits, aheavy catalytic subunit and a light regulatory subunit. This locusencodes the catalytic subunit, while the regulatory subunit isderived from a different gene located on chromosome 1p22-p21.Mutations at this locus have been associated with hemolytic anemiadue to deficiency of gamma-glutamylcysteine synthetase andsusceptibility to myocardial infarction.
Man, B.L., et al. J Clin Neurosci 17(10):1244-1247(2010)Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) :Le, T.M., et al. Mol. Genet. Metab. 101(1):55-61(2010)Fullerton, J.M., et al. Bipolar Disord 12(5):550-556(2010)Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.