|Other Names||Vascular endothelial growth factor C, VEGF-C, Flt4 ligand, Flt4-L, Vascular endothelial growth factor-related protein, VRP, VEGFC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.|
|Tissue Location||Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theplatelet-derived growth factor/vascular endothelial growth factor(PDGF/VEGF) family, is active in angiogenesis and endothelial cellgrowth, and can also affect the permeability of blood vessels.This secreted protein undergoes a complex proteolytic maturation,generating multiple processed forms which bind and activate VEGFR-3receptors. Only the fully processed form can bind and activateVEGFR-2 receptors. This protein is structurally and functionallysimilar to vascular endothelial growth factor D. [provided byRefSeq].
Chen, X., et al. Cancer Sci. 101(11):2384-2390(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Deguchi, K., et al. Anticancer Res. 30(6):2361-2366(2010)Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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