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PCDHB15 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9Y5E8
Clone Names 101008043
Peptide ID 101008043
Additional Information
Other Names Protocadherin beta-15, PCDH-beta-15, PCDHB15
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCDHB15
Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Cellular Location Cell membrane; Single-pass type I membrane protein EMBL; AF152494; AAD43755.1; -; mRNA EMBL; AF217742; AAK51610.1; -; mRNA EMBL; BC038797; AAH38797.1; -; mRNA CCDS; CCDS4257.1; - RefSeq; NP_061758.1; NM_018935.3 UniGene; Hs.130757; - ProteinModelPortal; Q9Y5E8; - SMR; Q9Y5E8; - BioGrid; 121061; 25 IntAct; Q9Y5E8; 25 STRING; 9606.ENSP00000231173; - iPTMnet; Q9Y5E8; - PhosphoSitePlus; Q9Y5E8; - BioMuta; PCDHB15; - DMDM; 13431379; - EPD; Q9Y5E8; - PaxDb; Q9Y5E8; - PeptideAtlas; Q9Y5E8; - PRIDE; Q9Y5E8; - ProteomicsDB; 86347; - DNASU; 56121; - Ensembl; ENST00000231173; ENSP00000231173; ENSG00000113248 GeneID; 56121; - KEGG; hsa:56121; - UCSC; uc003lje.5; human CTD; 56121; - EuPathDB; HostDB:ENSG00000113248.5; - GeneCards; PCDHB15; - HGNC; HGNC:8686; PCDHB15 HPA; CAB026471; - HPA; HPA007172; - HPA; HPA074676; - MIM; 604967; gene MIM; 606341; gene neXtProt; NX_Q9Y5E8; - OpenTargets; ENSG00000113248; - PharmGKB; PA33031; - eggNOG; KOG3594; Eukaryota eggNOG; ENOG410XQHI; LUCA GeneTree; ENSGT00900000140770; - HOGENOM; HOG000220892; - HOVERGEN; HBG054878; - InParanoid; Q9Y5E8; - KO; K16494; - OMA; RVVSEDN; - OrthoDB; EOG091G024L; - PhylomeDB; Q9Y5E8; - TreeFam; TF332299; - GeneWiki; PCDHB15; - GenomeRNAi; 56121; - PRO; PR:Q9Y5E8; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000113248; - CleanEx; HS_PCDHB15; - ExpressionAtlas; Q9Y5E8; baseline and differential Genevisible; Q9Y5E8; HS GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc GO; GO:0005509; F:calcium ion binding; IEA:InterPro GO; GO:0007155; P:cell adhesion; TAS:ProtInc GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro GO; GO:0007399; P:nervous system development; TAS:ProtInc GO; GO:0007416; P:synapse assembly; IBA:GO_Central InterPro; IPR002126; Cadherin InterPro; IPR015919; Cadherin-like InterPro; IPR032455; Cadherin_C InterPro; IPR020894; Cadherin_CS InterPro; IPR013164; Cadherin_N InterPro; IPR030733; PCDHB15 PANTHER; PTHR24028:SF97; PTHR24028:SF97; 1 Pfam; PF00028; Cadherin; 5 Pfam; PF08266; Cadherin_2; 1 Pfam; PF16492; Cadherin_C_2; 1 PRINTS; PR00205; CADHERIN SMART; SM00112; CA; 5 SUPFAM; SSF49313; SSF49313; 6 PROSITE; PS00232; CADHERIN_1; 5 PROSITE; PS50268; CADHERIN_2; 6 2: Evidence at transcript level; Calcium; Cell adhesion; Cell membrane; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 26 CHAIN 27 787 Protocadherin beta-15 /FTId=PRO_0000003942 TOPO_DOM 27 690 Extracellular. TRANSMEM 691 711 Helical. TOPO_DOM 712 787 Cytoplasmic. DOMAIN 35 133 Cadherin 1. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 138 242 Cadherin 2. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 247 347 Cadherin 3. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 352 451 Cadherin 4. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 456 561 Cadherin 5. {ECO:0000255|PROSITE- ProRule:PRU00043} DOMAIN 568 671 Cadherin 6. {ECO:0000255|PROSITE- ProRule:PRU00043} CARBOHYD 418 418 N-linked (GlcNAc...) asparagine CARBOHYD 567 567 N-linked (GlcNAc...) asparagine VARIANT 474 474 S -> R (in dbSNP:rs618506) /FTId=VAR_019633 VARIANT 494 494 R -> Q (in dbSNP:rs618096) /FTId=VAR_019634 VARIANT 719 719 A -> V (in a breast cancer sample; somatic mutation) /FTId=VAR_036106 VARIANT 758 758 G -> V (in a breast cancer sample; somatic mutation) /FTId=VAR_036107 SEQUENCE 787 AA; 86329 MW; 8DE8D3A07B0B6A56 CRC64; MEPAGERFPE QRQVLILLLL LEVTLAGWEP RRYSVMEETE RGSFVANLAN DLGLGVGELA ERGARVVSED NEQGLQLDLQ TGQLILNEKL DREKLCGPTE PCIMHFQVLL KKPLEVFRAE LLVTDINDHS PEFPEREMTL KIPETSSLGT VFPLKKARDL DVGSNNVQNY NISPNSHFHV STRTRGDGRK YPELVLDTEL DREEQAELRL TLTAVDGGSP PRSGTVQILI LVLDANDNAP EFVQALYEVQ VPENSPVGSL VVKVSARDLD TGTNGEISYS LYYSSQEIDK PFELSSLSGE IRLIKKLDFE TMSSYDLDIE ASDGGGLSGK CSVSVKVLDV NDNFPELSIS SLTSPIPENS PETEVALFRI RDRDSGENGK MICSIQDDVP FKLKPSVENF YRLVTEGALD RETRAEYNIT ITITDLGTPR LKTEQSITVL VSDVNDNAPA FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPRDPHLPL TSLVSINTDN GHLFALQSLD YEALQAFEFR VGATDRGFPA LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDVAKHRL VVLVKDNGEP PRSATATLQV LLVDGFSQPY LPLPEAAPAQ AQADSLTVYL VVALASVSSL FLFSVFLFVA VRLCRRSRAA SVGRCSVPEG PFPGHLVDVS GTGTLSQSYQ YEVCLTGGSE SNDFKFLKPI FPNIVSQDSR RKSEFLE
Research Areas
Citations (0)

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This gene is a member of the protocadherin beta genecluster, one of three related gene clusters tandemly linked onchromosome five. The gene clusters demonstrate an unusual genomicorganization similar to that of B-cell and T-cell receptor geneclusters. The beta cluster contains 16 genes and 3 pseudogenes,each encoding 6 extracellular cadherin domains and a cytoplasmictail that deviates from others in the cadherin superfamily. Theextracellular domains interact in a homophilic manner to specifydifferential cell-cell connections. Unlike the alpha and gammaclusters, the transcripts from these genes are made up of only onelarge exon, not sharing common 3' exons as expected. These neuralcadherin-like cell adhesion proteins are integral plasma membraneproteins. Their specific functions are unknown but they most likelyplay a critical role in the establishment and function of specificcell-cell neural connections.


Vanhalst, K., et al. FEBS Lett. 495 (1-2), 120-125 (2001) :Wu, Q., et al. Genome Res. 11(3):389-404(2001)Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97(7):3124-3129(2000)

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$ 80.00
Cat# BP12017a
Availability: In Stock
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