|Other Names||Voltage-dependent calcium channel gamma-6 subunit, Neuronal voltage-gated calcium channel gamma-6 subunit, CACNG6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in heart left ventricle.|
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Provided below are standard protocols that you may find useful for product applications.
Voltage-dependent calcium channels are composed of fivesubunits. The protein encoded by this gene represents one of thesesubunits, gamma, and is one of two known gamma subunit proteins.This particular gamma subunit is an integral membrane protein thatis thought to stabilize the calcium channel in an inactive (closed)state. This gene is part of a functionally diverse eight-memberprotein subfamily of the PMP-22/EMP/MP20 family and is located in acluster with two family members that function as transmembrane AMPAreceptor regulatory proteins (TARPs). Alternative splicing resultsin multiple transcript variants. Variants in this gene have beenassociated with aspirin-intolerant asthma.
Lee, J.S., et al. BMC Med. Genet. 11, 138 (2010) :Chen, R.S., et al. Cell Biochem. Biophys. 47(2):178-186(2007)Chu, P.J., et al. Gene 280 (1-2), 37-48 (2001) :Burgess, D.L., et al. Genomics 71(3):339-350(2001)
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