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WRN Antibody (Center T802) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q14191
Clone Names 80612087
Peptide ID 80612087
Additional Information
Gene ID 7486
Other Names Werner syndrome ATP-dependent helicase, DNA helicase, RecQ-like type 3, RecQ3, Exonuclease WRN, 31--, RecQ protein-like 2, WRN, RECQ3, RECQL2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name WRN
Synonyms RECQ3, RECQL2
Function Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double- stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.
Cellular Location Nucleus, nucleolus. Nucleus Nucleus, nucleoplasm. Note=Gamma- irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation.
Research Areas
Citations (0)

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This gene encodes a member of the RecQ subfamily and theDEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNAhelicases are involved in many aspects of DNA metabolism, includingtranscription, replication, recombination, and repair. This proteincontains a nuclear localization signal in the C-terminus and showsa predominant nucleolar localization. It possesses an intrinsic 3'to 5' DNA helicase activity, and is also a 3' to 5' exonuclease.Based on interactions between this protein and Ku70/80 heterodimerin DNA end processing, this protein may be involved in the repairof double strand DNA breaks. Defects in this gene are the cause ofWerner syndrome, an autosomal recessive disorder characterized bypremature aging.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Perry, J.J., et al. J. Biol. Chem. 285(33):25699-25707(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Kobayashi, J., et al. Mech. Ageing Dev. 131(6):436-444(2010)Ehrenberg, M., et al. Mol. Vis. 16, 1771-1775 (2010) :

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$ 80.00
Cat# BP12078c
Availability: In Stock
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