|Other Names||Dynein light chain Tctex-type 3, Protein 91/23, T-complex-associated testis-expressed 1-like, DYNLT3, TCTE1L, TCTE1XL|
|Target/Specificity||The synthetic peptide sequence is selected from aa 10-25 of HUMAN DYNLT3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Note=Colocalizes with BUB3 at kinetochores specifically during prometaphase|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.
Apcarian, A., et al. J. Gen. Virol. 91 (PT 11), 2659-2663 (2010) :
Lo, K.W., et al. J. Biol. Chem. 282(15):11205-11212(2007)
Yeh, T.Y., et al. J. Cell. Sci. 118 (PT 15), 3431-3443 (2005) :
Douglas, M.W., et al. J. Biol. Chem. 279(27):28522-28530(2004)
Wilson, M.J., et al. Cell Motil. Cytoskeleton 49(4):229-240(2001)
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