|Other Names||Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial, CybS, CII-4, QPs3, Succinate dehydrogenase complex subunit D, Succinate-ubiquinone oxidoreductase cytochrome b small subunit, Succinate-ubiquinone reductase membrane anchor subunit, SDHD, SDH4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Complex II of the respiratory chain, which isspecifically involved in the oxidation of succinate, carrieselectrons from FADH to CoQ. The complex is composed of fournuclear-encoded subunits and is localized in the mitochondrialinner membrane. The subunit D protein is one of two integralmembrane proteins anchoring the complex to the matrix side of themembrane. Mutations in SDHD have been linked to hereditaryparaganglioma.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gill, A.J., et al. Hum. Pathol. 41(6):805-814(2010)Milosevic, D., et al. Clin. Biochem. 43 (7-8), 700-704 (2010) :Hermsen, M.A., et al. Cell. Oncol. 32(4):275-283(2010)Krawczyk, A., et al. Endokrynol Pol 61(1):43-48(2010)
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