|Other Names||Phospholipase D1, PLD 1, hPLD1, Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D1, PLD1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).|
|Cellular Location||Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Late endosome membrane; Lipid- anchor; Cytoplasmic side|
|Tissue Location||Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine.|
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Provided below are standard protocols that you may find useful for product applications.
Phosphatidylcholine (PC)-specific phospholipases D (PLDs;EC 220.127.116.11) catalyze the hydrolysis of PC to produce phosphatidicacid and choline. A range of agonists acting through Gprotein-coupled receptors and receptor tyrosine kinases stimulatethis hydrolysis. PC-specific PLD activity has been implicated innumerous cellular pathways, including signal transduction, membranetrafficking, and the regulation of mitosis (Hammond et al., 1995[PubMed 8530346]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Kang, D.W., et al. Cancer Res. 70(10):4233-4242(2010)Yin, H., et al. J. Biol. Chem. 285(18):13580-13588(2010)Kang, D.W., et al. PLoS ONE 5 (8), E12109 (2010) :
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