|Other Names||Poly(rC)-binding protein 2, Alpha-CP2, Heterogeneous nuclear ribonucleoprotein E2, hnRNP E2, PCBP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509).|
|Cellular Location||Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm|
|Tissue Location||Detected in all tissues examined.|
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The protein encoded by this gene appears to bemultifunctional. Along with PCBP-1 and hnRNPK, it is one of themajor cellular poly(rC)-binding proteins. The encoded proteincontains three K-homologous (KH) domains which may be involved inRNA binding. Together with PCBP-1, this protein also functions as atranslational coactivator of poliovirus RNA via a sequence-specificinteraction with stem-loop IV of the IRES, promoting poliovirus RNAreplication by binding to its 5'-terminal cloverleaf structure. Ithas also been implicated in translational control of the15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, andhepatitis A virus RNA. The encoded protein is also suggested toplay a part in formation of a sequence-specific alpha-globin mRNPcomplex which is associated with alpha-globin mRNA stability. Thismultiexon structural mRNA is thought to be retrotransposed togenerate PCBP-1, an intronless gene with functions similar to thatof PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 andPCBP4) which are thought to have arisen as a result of duplicationevents of entire genes. Thsi gene also has two processedpseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variantsencoding different isoforms have been found for this gene.
Eiring, A.M., et al. Cell 140(5):652-665(2010)Ogram, S.A., et al. Virology 397(1):14-22(2010)You, F., et al. Nat. Immunol. 10(12):1300-1308(2009)Fujimura, K., et al. Biochim. Biophys. Acta 1793(5):878-887(2009)Waggoner, S.A., et al. J. Biol. Chem. 284(14):9039-9049(2009)
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