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PSCD2 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q99418
Clone Names 101008060
Peptide ID 101008060
Additional Information
Gene ID 9266
Other Names Cytohesin-2, ARF exchange factor, ARF nucleotide-binding site opener, Protein ARNO, PH, SEC7 and coiled-coil domain-containing protein 2, CYTH2, ARNO, PSCD2, PSCD2L
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYTH2 (HGNC:9502)
Synonyms ARNO, PSCD2, PSCD2L
Function Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity).
Cellular Location Cell membrane; Peripheral membrane protein Cytoplasm. Cell projection {ECO:0000250|UniProtKB:P63034}. Cell projection, growth cone {ECO:0000250|UniProtKB:P63034}. Cell junction, tight junction {ECO:0000250|UniProtKB:P63034}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P63034}. Note=Both isoform 1 and isoform 2 are recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to plasma membrane (PubMed:17398095). In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas. {ECO:0000250|UniProtKB:P63034, ECO:0000269|PubMed:17398095}
Tissue Location Widely expressed.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the PSCDfamily. Members of this family have identical structuralorganization that consists of an N-terminal coiled-coil motif, acentral Sec7 domain, and a C-terminal pleckstrin homology (PH)domain. The coiled-coil motif is involved in homodimerization, theSec7 domain contains guanine-nucleotide exchange protein (GEP)activity, and the PH domain interacts with phospholipids and isresponsible for association of PSCDs with membranes. Members ofthis family appear to mediate the regulation of protein sorting andmembrane trafficking. The encoded protein exhibits GEP activity invitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Twotranscript variants encoding different isoforms have been found forthis gene.


Merkulova, M., et al. Biochim. Biophys. Acta 1797(8):1398-1409(2010)Torii, T., et al. J. Biol. Chem. 285(31):24270-24281(2010)White, D.T., et al. Mol. Biol. Cell 21(4):562-571(2010)Bouschet, T., et al. J. Cell. Sci. 120 (PT 15), 2489-2497 (2007) :Wu, C., et al. Proteomics 7(11):1775-1785(2007)

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$ 80.00
Cat# BP12239a
Availability: In Stock
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