|Other Names||Serine/arginine-rich splicing factor 7, Splicing factor 9G8, Splicing factor, arginine/serine-rich 7, SRSF7, SFRS7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Brain, liver, kidney and lung.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theserine/arginine (SR)-rich family of pre-mRNA splicing factors,which constitute part of the spliceosome. Each of these factorscontains an RNA recognition motif (RRM) for binding RNA and an RSdomain for binding other proteins. The RS domain is rich in serineand arginine residues and facilitates interaction between differentSR splicing factors. In addition to being critical for mRNAsplicing, the SR proteins have also been shown to be involved inmRNA export from the nucleus and in translation. Two transcriptvariants encoding different isoforms have been found for this gene.
Kimura, T., et al. Med Mol Morphol 43(3):145-157(2010)Escudero-Paunetto, L., et al. Virology 401(2):155-164(2010)Manley, J.L., et al. Genes Dev. 24(11):1073-1074(2010)Valente, S.T., et al. Mol. Cell 36(2):279-289(2009)Shepard, P.J., et al. Genome Biol. 10 (10), 242 (2009) :
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