|Other Names||Matrix extracellular phosphoglycoprotein, Osteoblast/osteocyte factor 45, OF45, MEPE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes renal phosphate excretion and inhibits intestinal phosphate absorption (PubMed:14962809, PubMed:19005008). Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:18162525, PubMed:19998030, PubMed:22766095). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation (PubMed:22341070).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed by osteoblasts (PubMed:10945470, PubMed:11414762, PubMed:15108058). Expressed by stem cells in dental pulp (PubMed:15153459). Expressed by mesenchymal cells in dental papilla and dental pulp (PubMed:18547474, PubMed:22341070) Expressed in teeth, specifically in decidious dentin (PubMed:20581062). Expressed in ondotoblasts (PubMed:12489176) Expressed in salivary glands (PubMed:15329369). Secreted from oncogenic hypophosphatemic tumors (PubMed:11414762)|
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Provided below are standard protocols that you may find useful for product applications.
MEPE seems to play a role in mineralization.
Boskey, A.L., et al. Calcif. Tissue Int. 86(1):42-46(2010)Pereira, R.C., et al. Bone 45(6):1161-1168(2009)Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Rivadeneira, F., et al. Nat. Genet. 41(11):1199-1206(2009)Marks, J., et al. J. Am. Soc. Nephrol. 19(12):2313-2320(2008)
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