|Other Names||Diphthamide biosynthesis protein 7, WD repeat-containing protein 85, DPH7, C9orf112, WDR85|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).|
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Provided below are standard protocols that you may find useful for product applications.
WDR85 is a WD repeat-containing protein that plays a rolein the first step of diphthamide biosynthesis (Carette et al., 2009[PubMed 19965467]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Carette, J.E., et al. Science 326(5957):1231-1235(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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