|Other Names||Peroxisomal membrane protein PEX14, PTS1 receptor-docking protein, Peroxin-14, Peroxisomal membrane anchor protein PEX14, PEX14|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.|
|Cellular Location||Peroxisome membrane; Peripheral membrane protein; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an essential component of theperoxisomal import machinery. The protein is integrated intoperoxisome membranes with its C-terminus exposed to the cytosol,and interacts with the cytosolic receptor for proteins containing aPTS1 peroxisomal targeting signal. The protein also functions as atranscriptional corepressor and interacts with a histonedeacetylase. A mutation in this gene results in one form ofZellweger syndrome.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Macgregor, S., et al. Hum. Mol. Genet. 19(13):2716-2724(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Shiozawa, K., et al. J. Biol. Chem. 284(37):25334-25342(2009)
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