|Other Names||Neural retina-specific leucine zipper protein, NRL, NRL, D14S46E|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in the brain and the retina (PubMed:11477108). Expressed strongly in rod and cone cells (at protein level) (PubMed:11477108).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a basic motif-leucine zippertranscription factor of the Maf subfamily. The encoded protein isconserved among vertebrates and is a critical intrinsic regulatorof photoceptor development and function. Mutations in this genehave been associated with retinitis pigmentosa and retinaldegenerative diseases.
Roger, J.E., et al. J. Biol. Chem. 285(33):25637-25644(2010)Yang, Y., et al. Invest. Ophthalmol. Vis. Sci. 51(4):2229-2235(2010)Kanda, A., et al. Hum. Mutat. 28(6):589-598(2007)Khanna, H., et al. J. Biol. Chem. 281(37):27327-27334(2006)Nishiguchi, K.M., et al. Proc. Natl. Acad. Sci. U.S.A. 101(51):17819-17824(2004)
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