|Other Names||Pachytene checkpoint protein 2 homolog, Human papillomavirus type 16 E1 protein-binding protein, 16E1-BP, HPV16 E1 protein-binding protein, Thyroid hormone receptor interactor 13, Thyroid receptor-interacting protein 13, TR-interacting protein 13, TRIP-13, TRIP13, PCH2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that interacts with thyroidhormone receptors, also known as hormone-dependent transcriptionfactors. The gene product interacts specifically with the ligandbinding domain. This gene is one of several that may play a role inearly-stage non-small cell lung cancer.
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Kang, J.U., et al. Cancer Genet. Cytogenet. 182(1):1-11(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Kim, H.J., et al. Immunol. Lett. 95(2):155-159(2004)Suzuki, H., et al. Genome Res. 11(10):1758-1765(2001)
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