|Other Names||S-adenosylmethionine synthase isoform type-1, AdoMet synthase 1, Methionine adenosyltransferase 1, MAT 1, Methionine adenosyltransferase I/III, MAT-I/III, MAT1A, AMS1, MATA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.|
|Tissue Location||Expressed in liver.|
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Provided below are standard protocols that you may find useful for product applications.
This gene catalyzes a two-step reaction that involves thetransfer of the adenosyl moiety of ATP to methionine to formS-adenosylmethionine and tripolyphosphate, which is subsequentlycleaved to PPi and Pi. S-adenosylmethionine is the source of methylgroups for most biological methylations. The encoded protein isfound as a homotetramer (MAT I) or a homodimer (MAT III) whereas athird form, MAT II (gamma), is encoded by the MAT2A gene. Mutationsin this gene are associated with methionine adenosyltransferasedeficiency.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Wu, S.M., et al. Cell. Mol. Life Sci. 67(11):1831-1843(2010)Lai, C.Q., et al. Am. J. Clin. Nutr. 91(5):1377-1386(2010)Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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