|Other Names||Transmembrane 4 L6 family member 1, Membrane component chromosome 3 surface marker 1, Tumor-associated antigen L6, TM4SF1, M3S1, TAAL6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Multi-pass membrane protein. Note=Colocalizes with SDCBP2 in the apical region of the cell (PubMed:11102519).|
|Tissue Location||Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of thetransmembrane 4 superfamily, also known as the tetraspanin family.Most of these members are cell-surface proteins that arecharacterized by the presence of four hydrophobic domains. Theproteins mediate signal transduction events that play a role in theregulation of cell development, activation, growth and motility.This encoded protein is a cell surface antigen and is highlyexpressed in different carcinomas.
Gordon, G.J., et al. J. Natl. Cancer Inst. 101(9):678-686(2009)Lekishvili, T., et al. J. Cell. Sci. 121 (PT 5), 685-694 (2008) :Stelzl, U., et al. Cell 122(6):957-968(2005)Chang, Y.W., et al. Int. J. Cancer 116(2):243-252(2005)Kao, Y.R., et al. Clin. Cancer Res. 9(7):2807-2816(2003)
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