|Other Names||Ecto-NOX disulfide-thiol exchanger 2, APK1 antigen, Cytosolic ovarian carcinoma antigen 1, Tumor-associated hydroquinone oxidase, tNOX, Hydroquinone [NADH] oxidase, 1---, Protein disulfide-thiol oxidoreductase, 1---, ENOX2, COVA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.|
|Cellular Location||Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated|
|Tissue Location||Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells|
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The protein encoded by this gene is a growth-related cellsurface protein. It was identifed because it reacts with themonoclonal antibody KI in cells, such as the ovarian carcinoma lineOVCAR-3, also expressing the CAKI surface glycoprotein. The encodedprotein has two enzymatic activities: catalysis of hydroquinone orNADH oxidation, and protein disulfide interchange. The twoactivities alternate with a period length of about 24 minutes. Theencoded protein also displays prion-like properties. Two transcriptvariants encoding different isoforms have been found for this gene.
Morre, D.M., et al. Rejuvenation Res 13 (2-3), 162-164 (2010) :Morre, D.M., et al. Biofactors 34(3):237-244(2009)Mao, L.C., et al. FEBS Lett. 582 (23-24), 3445-3450 (2008) :Liu, S.C., et al. Biochem. Biophys. Res. Commun. 365(4):672-677(2008)Tang, X., et al. Oncol. Res. 16(12):557-567(2007)
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