|Other Names||Leucine zipper putative tumor suppressor 1, F37/esophageal cancer-related gene-coding leucine-zipper motif, Fez1, LZTS1, FEZ1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.|
|Cellular Location||Cytoplasm. Cell membrane. Cell projection, dendritic spine Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse Note=Associated with the plasma membrane and with microtubules Detected in dendritic spines, especially in the postsynaptic density (By similarity).|
|Tissue Location||Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines|
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This gene encodes a tumor suppressor protein that isubiquitously expressed in normal tissues. In uveal melanomas,expression of this protein is silenced in rapidly metastasizing andmetastatic tumor cells but has normal expression in slowlymetastasizing or nonmetastasizing tumor cells. This protein mayhave a role in cell-cycle control by interacting with theCdk1/cyclinB1 complex. This gene is located on chromosomal region8p22. Loss of heterozygosity (LOH) in the 8p arm is a commoncharacteristic of many types of cancer.
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Chattopadhyay, I., et al. Mutat. Res. 696(2):130-138(2010)Califano, D., et al. J. Cell. Physiol. 222(2):382-386(2010)Shyn, S.I., et al. Mol. Psychiatry (2009) In press :Canova, C., et al. Cancer Res. 69(7):2956-2965(2009)
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