|Other Names||Ras-related GTP-binding protein C, Rag C, RagC, GTPase-interacting protein 2, TIB929, RRAGC (HGNC:19902)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.|
|Cellular Location||Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942)|
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Provided below are standard protocols that you may find useful for product applications.
RRAGC is a monomeric guanine nucleotide-binding protein,or G protein. By binding GTP or GDP, small G proteins act asmolecular switches in numerous cell processes and signalingpathways.
Sekiguchi, T., et al. J. Biol. Chem. 279(9):8343-8350(2004)Sekiguchi, T., et al. J. Biol. Chem. 276(10):7246-7257(2001)Horwitz, M.S. Virology 279(1):1-8(2001)
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