|Other Names||Pyrin domain-containing protein 1, PAAD-only protein 1, Pyrin-only protein 1, PYDC1, ASC2, ASCI, POP1, PYC1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13124c was selected from the Center region of PYDC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.|
|Cellular Location||Cytoplasm. Note=Recruited to specks formed by PYCARD within the cytoplasm|
|Tissue Location||Predominantly expressed in monocytes, macrophages and granulocytes.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
PYDC1 associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
Son, Y.L., et al. Biochem. J. 410(2):319-330(2008)Natarajan, A., et al. J. Biol. Chem. 281(42):31863-31875(2006)Espejo, F., et al. Biochem. Biophys. Res. Commun. 340(3):860-864(2006)Stehlik, C., et al. Biochem. J. 373 (PT 1), 101-113 (2003) :Pawlowski, K., et al. Trends Biochem. Sci. 26(2):85-87(2001)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.