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HOOK1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UJC3
Clone Names 100324147
Peptide ID 100324147
Additional Information
Gene ID 51361
Other Names Protein Hook homolog 1, h-hook1, hHK1, HOOK1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13130c was selected from the Center region of HOOK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HOOK1
Function Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q8BIL5}. Cytoplasm, cytoskeleton Note=Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosomes, or mitochondria (By similarity). Often found in close association with microtubules (By similarity). Does not associate with the Golgi complex. During spermiogenesis, it localizes to the manchette in spermatids from steps 8-10. It is also present between the microtubule manchette and the nucleus. During manchette elongation, it is preferentially localized to the nuclear ring of the manchette, whereas the strong localization to the manchette decreases. In more mature spermatids, while the manchette migrates posteriorly, it localizes to punctuates spots. At later stages of spermatid differentiation, the punctuate expression pattern is found at both the attachment site and the proximal end of the elongated manchette. In contrast, it is not present in mature spermatozoa (By similarity) {ECO:0000250|UniProtKB:Q8BIL5}
Research Areas
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This gene encodes a member of the hook family ofcoiled-coil proteins, which bind to microtubules and organellesthrough their N- and C-terminal domains, respectively. The encodedprotein localizes to discrete punctuate subcellular structures, andinteracts with several members of the Rab GTPase family involved inendocytosis. It is thought to link endocytic membrane traffickingto the microtubule cytoskeleton. Several alternatively splicedtranscript variants have been identified, but the full-lengthnature of some of these variants has not been determined. [providedby RefSeq].


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Xu, L., et al. Mol. Biol. Cell 19(12):5059-5071(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Simpson, F., et al. Traffic 6(6):442-458(2005)

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$ 80.00
Cat# BP13130c
Availability: In Stock
Bulk Size
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