|Other Names||GMP reductase 2, Guanosine 5'-monophosphate oxidoreductase 2, Guanosine monophosphate reductase 2, GMPR2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13208a was selected from the N-term region of GMPR2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).|
|Tissue Location||Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
GMPR2 catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.
Lamesch, P., et al. Genomics 89(3):307-315(2007)Zhang, J., et al. J. Cancer Res. Clin. Oncol. 129(2):76-83(2003)Deng, Y., et al. Int. J. Biochem. Cell Biol. 34(9):1035-1050(2002)
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