|Other Names||Glycoprotein hormone beta-5, Thyrostimulin subunit beta, GPHB5, GPB5, ZLUT1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13233b was selected from the C-term region of GPHB5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.|
|Tissue Location||Highly expressed in brain and at low levels in pituitary. Also found in retina, testis and skin but not in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid, brain or adrenal gland. In pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs|
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Provided below are standard protocols that you may find useful for product applications.
GPHB5 is a cystine knot-forming polypeptide and a subunitof the dimeric glycoprotein hormone family (Hsu et al., 2002[PubMed 12089349]).
Suzuki, C., et al. Endocrinology 150(5):2237-2243(2009)Okajima, Y., et al. Regul. Pept. 148 (1-3), 62-67 (2008) :Okada, S.L., et al. Mol. Endocrinol. 20(2):414-425(2006)Sudo, S., et al. Endocrinology 146(8):3596-3604(2005)Heilig, R., et al. Nature 421(6923):601-607(2003)
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