|Other Names||Synaptonemal complex protein SC65, Leprecan-like protein 4, Nucleolar autoantigen No55, LEPREL4, NOL55, SC65|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13238b was selected from the C-term region of SC65. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly.|
|Cellular Location||Endoplasmic reticulum|
|Tissue Location||Detected in fibroblasts (at protein level) (PubMed:23959653). Detected in spleen, prostate, testis, ovary, colon, pancreas, kidney, placenta and heart (PubMed:10952778)|
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Provided below are standard protocols that you may find useful for product applications.
This nucleolar protein was first characterized because itwas an autoantigen in cases on interstitial cystitis. The protein,with a predicted molecular weight of 50 kDa, appears to belocalized in the particulate compartment of the interphasenucleolus, with a distribution distinct from that of nucleolarprotein B23. During mitosis it is associated with chromosomes.
Foster, L.J., et al. J. Proteome Res. 5(1):64-75(2006)Fossa, A., et al. Br. J. Cancer 83(6):743-749(2000)Ochs, R.L., et al. Mol. Biol. Cell 7(7):1015-1024(1996)
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