|Other Names||ELAV-like protein 3, Hu-antigen C, HuC, Paraneoplastic cerebellar degeneration-associated antigen, Paraneoplastic limbic encephalitis antigen 21, ELAVL3, HUC, PLE21|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13333a was selected from the N-term region of ELAVL3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.|
|Tissue Location||Brain specific.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
A member of the ELAVL protein family, ELAV-like 3 is aneural-specific RNA-binding protein which contains three RNP-typeRNA recognition motifs. The observation that ELAVL3 is one ofseveral Hu antigens (neuronal-specific RNA-binding proteins)recognized by the anti-Hu serum antibody present in sera frompatients with paraneoplastic encephalomyelitis and sensoryneuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Twoalternatively spliced transcript variants encoding distinctisoforms have been found for this gene.
Behrends, U., et al. Int. J. Cancer 100(6):669-677(2002)Park, S., et al. Mol. Cell. Biol. 20(13):4765-4772(2000)King, P.H. Nucleic Acids Res. 28 (7), E20 (2000) :Sakai, K., et al. Biochem. Biophys. Res. Commun. 256(2):263-268(1999)Van Tine, B.A., et al. Genomics 53(3):296-299(1998)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.